Nestled on 200 acres in the rustic town of Vista (64 km northeast of San Diego), Cal-a-Vie is a luxury health spa and resort. It has a European-style spa philosophy mixed with Californian concepts of health, fitness and nutrition. At Cal-a-Vie, you get your own Mediterranean-style villa with views of the rolling valley from the private balcony.

Packages are for three, four or seven days and include hiking trips, spa and beauty treatments. It's the only destination spa in the U.S. with its own 18-hole golf course.

Pricing: $$$$$